reported identifying one missense nucleotide mutation from C to G resulting in a substitution of serine with cysteine at codon 311 in the third intracellular loop of the dopamine D2 receptor in schizophrenics. Arinami et al. 119941 reported finding a positive association between the Cys311 variant a
No association detected between a D3 receptor gene-expressed variant and schizophrenia
β Scribed by Rothschild, Leelach G.; Badner, Judith; Cravchik, Anibal; Gershon, Elliot S.; Gejman, Pablo V.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 11 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(19960409)67:2<232::aid-ajmg18>3.0.co;2-k
No coin nor oath required. For personal study only.
β¦ Synopsis
A missense polymorphism (glycine to serine) in the first exon of the dopamine D3 (DRD3) gene was examined in a sib-pairs schizophrenia collection by the transmission test for linkage disequilibrium (TDT).
No association due to linkage disequilibrium was detected using TDT. Additionally, no evidence for excess homozygosity was found.
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