✦ LIBER ✦

No association between a polymorphic CAG repeat in the human potassium channel gene hKCa3 and bipolar disorder

✍ Scribed by Guy, C.A.; Bowen, T.; Williams, N.; Jones, I.R.; McCandless, F.; McGuffin, P.; Owen, M.J.; Craddock, N.; O'Donovan, M.C.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 11 KB
Volume: 88
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19990205)88:1<57::aid-ajmg10>3.0.co;2-6

No coin nor oath required. For personal study only.

✦ Synopsis

A recent case-control study suggested that modest enlargements of a CAG repeat in the hKCa3 potassium channel may be associated with bipolar disorder. We tried to replicate this result in a UK Caucasian sample of 203 DSM-IV bipolar I disorder patients and 206 controls group-matched for age and sex. Using the same model of analysis as the earlier study, bipolar probands did not have a higher frequency of alleles with greater than 19 repeats than controls ( 2 = 1.44, 1 df, P = 0.23). Similarly, comparison of the distributions of repeat sizes between probands and controls did not approach statistical significance (Mann-Whitney U test, P = 0.35). We conclude that our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to bipolar disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:57-60, 1999.

📜 SIMILAR VOLUMES

Lack of association between the hSKCa3 c

Lack of association between the hSKCa3 channel gene CAG polymorphism and schizophrenia

✍ Joober, Ridha; Benkelfat, Chawki; Brisebois, Kateri; Toulouse, Andr�; Lafreni�re 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 18 KB 👁 2 views

Genetic anticipation, a phenomenon characterized by increased severity of symptoms and earlier age at onset of a disease in successive generations, is believed to be present in schizophrenia. In several neurodegenerative diseases showing anticipation, the mutation causing the disease is an expanded

Lack of association between dopamine tra

Lack of association between dopamine transporter gene polymorphisms and delusional disorder

✍ Persico, Antonio M.; Catalano, Marco 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 9 KB 👁 2 views

Potential contributions of dopamine transporter (DAT) gene variants to delusional disorder were investigated using association analysis. DAT gene VNTR polymorphisms were assessed in 61 delusional patients and 54 normal controls. No differences were found in either genotypic or allelic distributions.

CAG repeat sequences in bipolar affectiv

CAG repeat sequences in bipolar affective disorder: No evidence for association in a french population

✍ Zander, Cecilia; Sch�rhoff, Franck; Laurent, Claudine; Chavand, Olivier; Bellivi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 19 KB 👁 2 views

Anticipation has been described in bipolar affective disorder (BPAD). However, there are conflicting results from association studies screening for a link between BPAD and CAG/CTG repeat expansions, the molecular basis of anticipation in several hereditary neurodegenerative disorders. Here, the repe

No association between serotonin transpo

No association between serotonin transporter gene polymorphisms and personality traits

✍ Gustavsson, J. Petter; N�then, Markus M.; J�nsson, Erik G.; Neidt, Helge; Forslu 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 51 KB 👁 2 views

Human family and twin studies have established considerable heritable components in personality traits as assessed by selfreport questionnaires. Recently, an association between a functional polymorphism in the upstream regulatory region of the serotonin transporter gene and neuroticismrelated perso

Genetic associations with clinical chara

Genetic associations with clinical characteristics in bipolar affective disorder and recurrent unipolar depressive disorder

✍ Ho, Luk W.; Furlong, Robert A.; Rubinsztein, Judy S.; Walsh, Cathy; Paykel, Euge 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 30 KB 👁 2 views

Genetic factors may be associated with disease subtype as well as susceptibility. We have therefore typed polymorphisms at the serotonin transporter, dopamine receptor, tryptophan hydroxylase, tyrosine hydoxylase, and monoamine oxidase A (MAOA) loci in 139 unipolar and 131 bipolar patients and inves

Analysis of GNAZ gene polymorphism in bi

Analysis of GNAZ gene polymorphism in bipolar affective disorder

✍ Saito, Takuya; Papolos, Demitri F.; Chernak, Danielle; Rapaport, Mark H.; Kelsoe 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 16 KB 👁 2 views

Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein ␣ subunit gene G␣z (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation po