NMR studies of organic polymorphs & solvates
โ Scribed by Harris, Robin K.
- Book ID
- 118250046
- Publisher
- Royal Society of Chemistry
- Year
- 2006
- Tongue
- English
- Weight
- 735 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0003-2654
- DOI
- 10.1039/b516057j
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NMR and XRD data are reported for several new forms of finasteride, including the results of complete structure determinations for three solvates. Form III of finasteride, hitherto only mentioned in the patent literature, and a new anhydrous form designated Form X, have been found in mixtures of pol
The phenomenon of polymorphism is prevalent in pharmaceuticals, yet it is unusual to identify more than three or four forms for any particular drug. Terazosin hydrochloride has been found to exist at room temperature in four solvent-free forms that can be isolated directly, one solvent-free form tha