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High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids

✍ Scribed by Sherry L. Morissette; Örn Almarsson; Matthew L. Peterson; Julius F. Remenar; Michael J. Read; Anthony V. Lemmo; Steve Ellis; Michael J. Cima; Colin R. Gardner

Book ID: 111865528
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 804 KB
Volume: 56
Category: Article
ISSN: 0169-409X
DOI: 10.1016/j.addr.2003.10.020

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## Abstract 18‐Crown[6] ether has been used to prepare a new class of organic–inorganic complexes of general formula 18‐crown[6]⋅M[HSO~4~]~__n__~ (where M = NH~4~^+^, K^+^, Sr^2+^ and __n__ = 1, 2) by reacting directly in solution or in the solid state the crown ether 18‐crown[6] with inorganic sal