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Identification, preparation, and characterization of several polymorphs and solvates of terazosin hydrochloride

โœ Scribed by J. Bauer; J. Morley; S. Spanton; F.J.J. Leusen; R. Henry; S. Hollis; W. Heitmann; A. Mannino; J. Quick; W. Dziki

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
258 KB
Volume
95
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

The phenomenon of polymorphism is prevalent in pharmaceuticals, yet it is unusual to identify more than three or four forms for any particular drug. Terazosin hydrochloride has been found to exist at room temperature in four solvent-free forms that can be isolated directly, one solvent-free form that can be prepared by desolvation of a methanolate, a methanol solvate, and a dihydrate. This study presents characterization and methods for preparation of each of these forms. Data are also presented demonstrating the relative stability of these forms.

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