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NMR spectra and structures of oridonin derivatives complexes with β-cyclodextrin

✍ Scribed by Wei Liu; Bing Zhao; Yin-Chao Li; Hong-Min Liu

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
245 KB
Volume
49
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

Complexations between three oridonin derivatives and β‐cyclodextrin (βCD) were studied by nuclear magnetic resonance (NMR) method. Job's plots for complexes were depicted by ^1^H NMR spectra chemical shifts, which proved the 1:1 stoichiometry inclusion complex formation between each derivative and βCD. Two‐dimensional rotating frame overhauser effect spectroscopy (2D ROESY) support the above conclusion and also proved that ring A of each oridonin derivative deeply enters into hydrophobic cavity from the wider rim and the other parts are outside the cavity. Apparent formation constants (K~a~) of complexes between three oridonin derivatives and two CDs are calculated according to Scott's equation. Copyright © 2011 John Wiley & Sons, Ltd.

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