NMR imaging of 15N at natural abundance
β Scribed by P Kinchesh; E.W Randall; S.C.R Williams
- Book ID
- 107798594
- Publisher
- Elsevier Science
- Year
- 1992
- Weight
- 243 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0022-2364
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The 1H/15N HMBC experiment at 15N natural abundance using pulsed Γeld gradients is a useful tool for chemical shift assignment and structure elucidation. This experiment assisted in the identiΓcation of regioisomers that could not be distinguished with conventional 1H/1H nuclear Overhauser or 1H/13C
Early e β orts to utilize 15N NMR spectroscopy in structure elucidation studies were often frustrated by the low gyromagnetic ratio and the low natural abundance (0.37%) of the nuclide. The advent of 1H and (c N ) inverse-detected 2D NMR methods has eliminated many of the difficulties inherent to the
## Abstract ^15^N chemical shifts of twentyβfour substituted indoles have been determined in natural abundance (in organic solvents) using Fourier transform NMR. The overall chemical shift range is 27 ppm, with groups in the 2β, 3β and 5βring positions showing the largest substituent effects. Subst