Conformational analysis of gramicidin A by 15N NMR at natural abundance
β Scribed by Geoffrey E Hawkes; Lu Yun Lian; Edward W Randall
- Book ID
- 103191924
- Publisher
- Elsevier Science
- Year
- 1984
- Weight
- 244 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0022-2364
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## Abstract The naturalβabundance ^15^Nβnuclear magnetic resonance (nmr) spectrum of the cyclic decapeptide gramicidin S has been measured and assigned in the solvents dimethyl sulfoxide, methanol, and 2,2,2βtrifluoroethanol. Three methods have been investigated to distinguish between peptide group
The 1H/15N HMBC experiment at 15N natural abundance using pulsed Γeld gradients is a useful tool for chemical shift assignment and structure elucidation. This experiment assisted in the identiΓcation of regioisomers that could not be distinguished with conventional 1H/1H nuclear Overhauser or 1H/13C