NMR evidence for self-association of theophylline in aqueous solution
β Scribed by Arvind L. Thakkar; Lowell G. Tensmeyer; William L. Wilham
- Publisher
- John Wiley and Sons
- Year
- 1971
- Tongue
- English
- Weight
- 293 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
The self-association of the amphiphilic drug verapamil hydrochloride in water and in the presence of added electrolyte (0.0-0.009 mol kg -1 NaCl) has been studied by light-scattering and NMR techniques. Critical micelle concentrations were determined from inflections in the data from both techniques
## Abstract The ^1^H NMR spectrum of chlorpromazine hydrochloride was fully assigned at 400 MHz. Similarly, the ^13^C NMR spectrum was assigned unambiguously using twoβdimensional NMR. Measurements of chemical shift as a function of concentration in D~2~O showed appreciable changes of shift of both