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NMR 1H relaxation and NOESY studies of spiperone conformational features in solution

✍ Scribed by Charles E. Keller; W. Robert Carper

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
566 KB
Volume
31
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The high‐field ^1^H, ^19^F and ^13^C NMR spectra of spiperone in CDCl^3^ solution were analyzed with the aid of homonuclear (H‐H‐COSY) and heteronuclear (H,C‐COSY) chemical shift correlation experiments. Multiple through‐space intersections were identified using phase‐sensitive nuclear Overhauser and exchange spectroscopy (NOESY). Proton relaxation rates and activation energies were determined over the temperature range −60 to 50°C. The chemical shift, NOESY and proton relaxation rate results support the formation of cyclic dimers and multiple spiperone conformations in solution.

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