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Conformational features of imipramine hydrochloride in aqueous solution as detected by 1H NMR relaxation analysis

✍ Scribed by Elena Gaggelli; Nadia Marchettini; Gianni Valensin

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
312 KB
Volume
29
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

Proton NMR measurements were performed and ^1^H^1^H dipolar interaction energies were measured to delineate the conformation of imipramine in solution. Self‐association of imipramine into dimers was observed and a dimerization constant of 121 mol^−1^ was calculated. The motional correlation times for the monomer and the dimer were calculated at τ~cm~ = 0.18 ns and τ~cd~ = 0.36 ns, respectively. The geometry of the self‐stacked dimer was analysed by measuring intermolecular dipolar cross‐relaxation rates and interpreted in terms of the conformation of the aminoalkyl moiety.

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