Nizatidine, N-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N′-methyl-2-nitro-1,1-ethenediamine
✍ Scribed by Gregory A. Stephenson; Timothy J. Wozniak; Joseph G. Stowell; Stephen R. Byrn
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 399 KB
- Volume
- 380
- Category
- Article
- ISSN
- 0022-2860
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📜 SIMILAR VOLUMES
A simple four-stage conversion of 2-1nethyl-4(5>nitroimidazole to 2-methyl-4(5)-nitr0['~N""]imidazole is reported. The method consists in N-nitration of the initial compound to ?-methyl-1,4-dinitroimidazole, treating the latter with ["Nlglycine and N-dealkylation of the obtained (~-rnethyl-4-nitro[~
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l
## Abstract 1,4‐Dinitro‐2‐methylimidazole reacts under mild conditions with glycine to yield (2‐methyl‐4‐nitro‐1‐imidazolyl)acetic acid. The use of [^15^N]glycine gives a product having a labelled nitrogen in 1 position of 4‐nitroimidazole.