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Nitrogen-15 NMR studies of 1,4-benzodiazepines: 2—The triazolobenzodiazepines

✍ Scribed by Terrence A. Scahill; Stanford L. Smith

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
300 KB
Volume
21
Category
Article
ISSN
0749-1581

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✦ Synopsis

Nitrogen-15 NMR data for a series of 21 triazolobenzodiazepines are presented, including "N chemical shifts and substitnent effects. Tbe line assignments made by correlation to other model compounds were confirmed by a shift reagent and protonation study. A Yb(dp& study on alprazolam showed that the molar shifts of the fonr nitrogens ranged from 35 to 150 ppm.

A number of 'H, I3C and ''NNMR studies of the common benzodiazepines have appeared in the literature.""

In Part I" we reported a I5NNMR extension of these studies to a series of triazolobenzodiazepines.

' ' N NMR OF 1,4-BENZODIAZEPDES 2. THE TRIAZOLOBENZODIAZEPINES

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