The synthesis of a novel enediyne 2, and its cytotoxicity and activation by the nitroreductase enzyme NR2 from Esherichia coli B, are described. In contrast to closely related analogues, 2 exhibits a 90-fold increase in cytotoxicity against UV4 cells in the presence of the enzyme and NADH, suggestin
โฆ LIBER โฆ
Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy
โ Scribed by Hu, Longqin; Yu, Chengzhi; Jiang, Yongying; Han, Jiye; Li, Zhuorong; Browne, Patrick; Race, Paul R.; Knox, Richard J.; Searle, Peter F.; Hyde, Eva I.
- Book ID
- 120194954
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 83 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-2623
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