๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy

โœ Scribed by Hu, Longqin; Yu, Chengzhi; Jiang, Yongying; Han, Jiye; Li, Zhuorong; Browne, Patrick; Race, Paul R.; Knox, Richard J.; Searle, Peter F.; Hyde, Eva I.


Book ID
120194954
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
83 KB
Volume
46
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


A novel enediyne prodrug for antibody-di
โœ M.P. Hay; W.R. Wilson; W.A. Denny ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 256 KB

The synthesis of a novel enediyne 2, and its cytotoxicity and activation by the nitroreductase enzyme NR2 from Esherichia coli B, are described. In contrast to closely related analogues, 2 exhibits a 90-fold increase in cytotoxicity against UV4 cells in the presence of the enzyme and NADH, suggestin

E. coli NfsA: an alternative nitroreduct
โœ Vass, S O; Jarrom, D; Wilson, W R; Hyde, E I; Searle, P F ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 359 KB

Prodrug activation gene therapy is a developing approach to cancer treatment, whereby prodrug-activating enzymes are expressed in tumour cells. After administration of a non-toxic prodrug, its conversion to cytotoxic metabolites directly kills tumour cells expressing the activating enzyme, whereas t