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Mustard Prodrugs for Activation by Escherichia coli Nitroreductase in Gene-Directed Enzyme Prodrug Therapy

โœ Scribed by Friedlos, Frank; Denny, William A.; Palmer, Brian D.; Springer, Caroline J.


Book ID
126943600
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
263 KB
Volume
40
Category
Article
ISSN
0022-2623

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The synthesis of a novel enediyne 2, and its cytotoxicity and activation by the nitroreductase enzyme NR2 from Esherichia coli B, are described. In contrast to closely related analogues, 2 exhibits a 90-fold increase in cytotoxicity against UV4 cells in the presence of the enzyme and NADH, suggestin