E. coli NfsA: an alternative nitroreduct
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Vass, S O; Jarrom, D; Wilson, W R; Hyde, E I; Searle, P F
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Article
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2009
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Nature Publishing Group
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English
β 359 KB
Prodrug activation gene therapy is a developing approach to cancer treatment, whereby prodrug-activating enzymes are expressed in tumour cells. After administration of a non-toxic prodrug, its conversion to cytotoxic metabolites directly kills tumour cells expressing the activating enzyme, whereas t