Nitriles in Heterocyclic Synthesis: Novel Synthesis of Pyrido-[2,1-b]benzothiazoles and 1,3-Benzothiazole Derivatives
โ Scribed by N. M. Fathy; F. M. Abdel Motti; G. E. H. Elgemeie
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 342 KB
- Volume
- 321
- Category
- Article
- ISSN
- 0365-6233
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๐ SIMILAR VOLUMES
## A simple route to the synthesis of the pharmaceutically important thieno[2,3-d]pyrimidine derivatives and of thieno[2,3-b]pyridine derivatives via the use of 5-amin0-3-phenylthiophene-2,Cdicarbonitrile (2) as a starting material is described.
## 2-Acetylbenzothiazole (1) reacts with dimethylformamide dimethylacetal (DMF-DMA) to afford the enaminone 2. Compound 2 reacts regioselectively with some nitrilimines 5a-d and nitrile oxides 6b-d to afford the novel pyrazole and isoxazole derivatives 11a-d and 12b-d, respectively, which react wi