Activated Nitriles in Heterocyclic Synthesis: Novel Syntheses of Pyrano[2,3-b]pyridines and Pyrano[2,3-d]pyrimidines
β Scribed by Galal E. H. Elgemeie; Abd El-Kerim; M. Gohar; Hassan A. Regaila; Hassan A. Elfahham
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 242 KB
- Volume
- 321
- Category
- Article
- ISSN
- 0365-6233
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π SIMILAR VOLUMES
## A simple route to the synthesis of the pharmaceutically important thieno[2,3-d]pyrimidine derivatives and of thieno[2,3-b]pyridine derivatives via the use of 5-amin0-3-phenylthiophene-2,Cdicarbonitrile (2) as a starting material is described.
The 2-chloro-3-formyl quinoline derivatives (1a-e) on treatment with acetic anhydride and sodium acetate, a β orded the corresponding novel 2-oxopyrano(2,3-b) quinoline derivatives (2a-e), and these were subjected to ammonia treatment to yield the corresponding naphthyridine derivatives (3a-e). The p