Synthesis of some novel 2-oxo-pyrano(2,3-b)- and 2-oxo-pyrido(2,3-b)quinoline derivatives as potential antimalarial, diuretic, clastogenic and antimicrobial agents

✍ Scribed by Marimuthu Sekar; Karnam J. Rajendra Prasad

• Publisher: Wiley (John Wiley & Sons)
• Year: 1998
• Tongue: English
• Weight: 196 KB
• Volume: 72
• Category: Article
• ISSN: 0268-2575
• DOI: 10.1002/(sici)1097-4660(199805)72:1<50::aid-jctb868>3.0.co;2-e

✦ Synopsis

The 2-chloro-3-formyl quinoline derivatives (1a-e) on treatment with acetic anhydride and sodium acetate, a †orded the corresponding novel 2-oxopyrano(2,3-b) quinoline derivatives (2a-e), and these were subjected to ammonia treatment to yield the corresponding naphthyridine derivatives (3a-e). The prepared compounds (2a-e) were tested for their antimalarial, diuretic, clastogenic and antimicrobial properties. Not all the compounds showed a diuretic e †ect and the signiÐcant increase in the frequency of micronuclei shows that they are nonclastogens, whereas the 7-chloro derivative (2e) was a very e †ective antimalarial agent against the mosquito species. All the compounds were found to have optimum antimicrobial activity against Staphylococcus aureus, Escherichia coli and Salmonella typhi. Compounds 2d and 2e were found to be most active against the bacteria tested.

1998 SCI (