## Abstract Nitric oxide (NO) is a biologically active inorganic molecule produced when the semiessential amino acid lβarginine is converted to lβcitrulline and NO via the enzyme nitric oxide synthase (NOS). NO is known to be involved in the regulation of many physiological processes, such as contr
Nitric oxide synthase
β Scribed by Karla Punkt; Andreas Naupert; Maren Wellner; Gerhard Asmussen; Christine Schmidt; Igor B. Buchwalow
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 795 KB
- Volume
- 118
- Category
- Article
- ISSN
- 1432-119X
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The enzyme nitric oxide synthase catalyzes the oxidation of the amino acid L-arginine to L-citrulline and nitric oxide in an NADPH-dependent reaction. Nitric oxide plays a critical role in signal transduction pathways in the cardiovascular and nervous systems and is a key component of the cytostatic
It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot and in situ hybridization analysis and a 131-kDa