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Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes

✍ Scribed by Jean E. Merrill; Sean P. Murphy; Branislava Mitrovic; Allan Mackenzie-Graham; Joel C. Dopp; Minzhen Ding; Jeannette Griscavage; Louis J. Ignarro; Charles J. Lowenstein

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
563 KB
Volume
48
Category
Article
ISSN
0360-4012

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✦ Synopsis

It has been previously demonstrated that microglia and astrocytes produce micromolar amounts of nitric oxide in vitro. In this study, we demonstrate that primary rat oligodendrocytes can be stimulated to produce iNOS mRNA as detected by Northern blot and in situ hybridization analysis and a 131-kDa iNOS protein by Western blot analysis; protein was also detected in cells by single- and double-label immunohistochemistry for iNOS and the oligodendrocyte-specific marker CNPase. NO/NOS are produced as a consequence of activation of the gene encoding the inducible nitric oxide synthase as determined by inhibition with actinomycin D and cyclohexamide. The iNOS is functional, leading to calcium/calmodulin-independent NO production in these in vitro cultures.

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