𝔖 Bobbio Scriptorium
✦   LIBER   ✦

New α,γ-cyclic peptides-nanotube molecular caps using α,α-dialkylated α-amino acids

✍ Scribed by César Reiriz; LUIS Castedo; Juan R. Granja

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
475 KB
Volume
14
Category
Article
ISSN
1075-2617

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We report here the preparation and structural characteristics of a novel self‐assembling peptide composed of alternating α,α‐dialkylated α‐amino and cis‐4‐aminocyclopent‐2‐enecarboxylic acids. The use of α,α‐dialkylated amino acids represents a novel method to prevent the formation of extensive β‐sheet‐like hydrogen‐bonding networks that are characteristic of peptide nanotubes. Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Enantio- and diastereoselective synthese
Enantio- and diastereoselective syntheses of cyclic Cα-tetrasubstituted α-amino acids and their use to induce stable conformations in short peptides
✍ Prantik Maity; Burkhard König 📂 Article 📅 2007 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 589 KB

## Abstract C^α^‐Tetrasubstituted α‐amino acids are widely used to design and prepare peptides and peptide mimics with constrained conformations. Subcategories of these compounds are cyclic C^α^‐tetrasubstituted α‐amino acids, in which both α‐substituents are covalently connected. This survey prese