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New Trimethylaluminum-Induced Mannich-Type Reaction of Hydrazones.

✍ Scribed by Laurent El Kaim; Laurence Grimaud; Yannick Perroux; Cornelia Tirla


Publisher
John Wiley and Sons
Year
2004
Weight
117 KB
Volume
35
Category
Article
ISSN
0931-7597

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Direct Catalytic Asymmetric Mannich-Type
✍ Yuta Suzuki; Ryo Yazaki; Naoya Kumagai; Masakatsu Shibasaki πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 403 KB πŸ‘ 1 views

## Abstract **Taking the reins**: The title transformation of thioamides and __N__‐diphenylphosphinoyl imines is described. By harnessing the power of cooperative catalysis between a soft Lewis acid and a hard BrΓΈnsted base, thioamide carbon pronucleophiles can furnish Mannich products (see scheme)