Ring opening of the glycidonitriles (II a-e) by HF/pyridine leads to the fluorocyanohydrins (III a-e). Treatment of the fluorocyanohydrins with ammonia in anhydrous methanol gives the a-amino-6-fluoronitriles (IV a-e) which upon acidic hydrol sis afford the s-fluoro-a-aminoacids (V a-e) in good over
New synthetic routes to β-fluoro-α-aminoacids A - from aziridinecarboxylates
✍ Scribed by A. Barama; R. Condom; R. Guedj
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 69 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-1139
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## Abstract For Abstract see ChemInform Abstract in Full Text.
a-Fluoro-a,b-unsaturated ketones were prepared from trifluoromethyl ketones via a sequence involving Mg metal promoted successive double defluorination. Trifluoromethyl ketones were transformed to b,b-difluoroenol silyl ethers which were then coupled with aldehydes and ketones to b-hydroxy-a,a-diflu
Treatment of 7C-(2,2.3-trihaloalkylideneamino)cephalosporins with excess methanol in the presence of acid scavenger gave 7p-(2-haloalk-2-enylideneamino)-7+methoxycephalosporins.