New synthesis of (RS)-carnitine chloride
โ Scribed by Sharon G. Boots; Marvin R. Boots
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 332 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## A short, efficient and enantioselective synthesis of both (R) and (S) enantiomers of Carnitine is reported starting with (R) or (S) malic acid and involving a chemoselective reduction step.
y-and a-hydroxyalkane-1-thiols, in many cases easily accessible over the chlorohydrins, are converted to y-and a-chloroalkylsulfonyl chlorides by the combined action of chlorine and water. A mechanism is suggested. This new synthesis method provides an easy way to obtain sultams.
## Abstract A method for the production of carboxyโlabelled lโcarnitine is described. The first step is the chemical synthesis of 4โNโtrimethylammoniobutanoate (butyrobetaine) from the precursors 4โaminobutanoate and iodomethane. The second step involves the hydroxylation of butyrobetaine to form l