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New strategy for the diastereoselective synthesis of bicyclic “pre-activated” analogues of cyclophosphamide

✍ Scribed by P. Maynard-Faure; C. Gonser; V. Vaime; D. Bouchu

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
346 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The dias~lective syathesis of "preactivated" analogues of cyclophc+amide in the 3-fbis(2-ehltrocthyl)amino]-2-aza-4$dioxa-3-phosphabicyclo(4.3.O)nonane 3-oxide series is described, using either the phosphcrylation of an azidoalcohol followed by a reductive cyclisation or the phospharylation of an ace&l alcohol followed by an unprecedent direct Lewis acid catalyzed it~tramde~ular substitution.

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