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New strategies to generate induced pluripotent stem cells

✍ Scribed by James O’Malley; Knut Woltjen; Keisuke Kaji

Book ID
108105382
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
219 KB
Volume
20
Category
Article
ISSN
0958-1669

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Pluripotent stem cells have been generated from mouse and human somatic cells by viral expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc. A major limitation of this technology is the use of potentially harmful genome-integrating viruses. Here, we generate mouse induced pluripotent