New Stereospecific Method of Synthesis of [Sp]- and [Rp]-Dinucleoside-(3',5') Methanephosphonates
β Scribed by Wozniak, Lucyna A.; Pyzowski, Jaroslaw; Wieczorek, Michal; Stec, Wojciech J.
- Book ID
- 127263206
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 474 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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AND Sp-PHOSPHOR3-[35S] TH I OATES Janina Baraniak, Wtadystaw ReimschUsselt , J u l i u s z Rudziriski t , and Wojciech J. Stec P o l i s h Academy o f Sciences, Centre o f M o l e c u l a r and Macromolecular Studies, Department o f B i o o r g a n i c Chemistry, 90-362 t 6 d i , Poland t l n s t i
RP,RP)-and (SP,SP)-diastereomers of thymidylyl(3',5')thymidyly1(3',5')thymidine di (O,O-phosphorothioate (6) were prepared in the stereospecific reaction of (RF)-or (SP)-isomer of 5'-0-monomethoxytritylthytnidine 3'U1~14-nitroph~nyl)-S-(X-nitrobenzyl)phosphorothioate] (2) with 5'-0tt activatd 3'Uace