Stereospecific synthesis of adenosine cyclic 3′,5′-RP- and SP-phosphoro-[35S]thioates
✍ Scribed by Janina Baraniak; Wtadystaw Reimschüssel; Juliusz Rudziński; Wojciech J. Stec
- Book ID
- 102370807
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 162 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
AND Sp-PHOSPHOR3-[35S] TH I OATES Janina Baraniak, Wtadystaw ReimschUsselt , J u l i u s z Rudziriski t , and Wojciech J. Stec P o l i s h Academy o f Sciences, Centre o f M o l e c u l a r and Macromolecular Studies, Department o f B i o o r g a n i c Chemistry, 90-362 t 6 d i , Poland t l n s t i t u t e o f A p p l i e d R a d i a t i o n Chemistry, Technical U n i v e r s i t y 90-924 td.di, Poland S UM t4A RY 2 ' 6 6 t r i b e n z o y l a d e n o s i n e c y c l i c 3',5'-phosphorani 1 i d a t e s Q) w i t h so-35 dium h y d r i d e and carbon [ S l d i s u l p h i d e gave, a f t e r removal of the p r o t e c t i v e groups, the d e s i r e d Rpand S p -d i a s t e r e o i s o m r s S t e r e o s p e c i f i c r e a c t i o n o f b o t h d i a s t e r e o i s o m e r s o f 0 ,N ,No f [35s]cAMps (2).
📜 SIMILAR VOLUMES
RP,RP)-and (SP,SP)-diastereomers of thymidylyl(3',5')thymidyly1(3',5')thymidine di (O,O-phosphorothioate (6) were prepared in the stereospecific reaction of (RF)-or (SP)-isomer of 5'-0-monomethoxytritylthytnidine 3'U1~14-nitroph~nyl)-S-(X-nitrobenzyl)phosphorothioate] (2) with 5'-0tt activatd 3'Uace