New stereocontrolled transformations in the imidazolosugar series
β Scribed by Kamil Weinberg; Stefan Jankowski; Didier Le Nouen; Andrzej Frankowski
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 138 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The isomeric imidazolopyrrolidinose 1, imidazolopiperidinose 2 and imidazoloazepanose 3, potential glycosidase inhibitors, were obtained in several steps from D-glucose.
π SIMILAR VOLUMES
## Abstrac-Oxidation of the non-phenolic aporphines nuciferine (1). dicentrine (3). ocopodine (4) and thalicarpine ( 7) by iodine affords the corresponding dehydroaporphines (2. 5. 6 and 8). In contrast. iodine oxidation of non-phenolic noraporphines proceeds all the way to the oxoaporphine stage:
Substitued N-(isoxazol-4-yl)thioureas 1 undergo a transformation in the presence of hexacarbonylmolybdenum and acid to yield functionalized thiazoles 3 in a one-pot reaction. In a few cases, 1,4,5-trisubstituted dihydroimidazoleth,iones 4 are also isolated as side products. Mechanistic consideration