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Transformations in the Isoxazole Series: Synthesis of Substituted 2-Aminothiazoles

✍ Scribed by Alfons Pascual

Publisher: John Wiley and Sons
Year: 1991
Tongue: German
Weight: 790 KB
Volume: 74
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19910740309

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✦ Synopsis

Substitued N-(isoxazol-4-yl)thioureas 1 undergo a transformation in the presence of hexacarbonylmolybdenum and acid to yield functionalized thiazoles 3 in a one-pot reaction. In a few cases, 1,4,5-trisubstituted dihydroimidazoleth,iones 4 are also isolated as side products. Mechanistic considerations are outlined and scope and limitations of this new methodology discussed. ') With samarium(I1) iodide, see [9a]; with hexacarbonylmolybdenum, see [2] [ 10); with dihydrolipoamideiron(II), see [9b].

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