New Safety-Catch Photolabile Protecting Group
β Scribed by Riguet, Emmanuel; Bochet, Christian G.
- Book ID
- 126257937
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 129 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
The use of two derivatives of 2-methoxy-4-methylsulfinylbenzyl alcohol is demonstrated as a safetycatch protecting group and linker for solid-phase peptide synthesis. The protecting group and linker are stable to TFA and are readily removed under reductive acidolytic conditions.
The N-(2-acetoxyethyl) group can be cleaved by a photoinduced single electron transfer to 4,4dimethoxybenzophenone.
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