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The N-(2-acetoxyethyl) group as a new photolabile protecting group
β Scribed by Janine Cossy; Haja Rakotoarisoa
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 89 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The N-(2-acetoxyethyl) group can be cleaved by a photoinduced single electron transfer to 4,4dimethoxybenzophenone.
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The use of the tris(trimethylsilyl)silyl (sisyl) group as a photolabile protecting group for primary and secondary alcohols was demonstrated. Sisyl ethers of a number of alcohols (yields 70-97%) were stable to many synthetic protocols, but could be deprotected using photolysis to give the starting a