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New Route to Metformin Hydrochloride (N,N-dimethylimidodicarbonimidic diamide hydrochloride) Synthesis

✍ Scribed by Shalmashi, Anvar


Book ID
118150378
Publisher
MDPI AG
Year
2008
Tongue
English
Weight
101 KB
Volume
2008
Category
Article
ISSN
1422-8599

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A Concise Route to Valacyclovir Hydrochl
✍ Prasada Raju V. N. K. V. Vetukuri; Ravindra Vedantham; Vijayavitthal Thippannach πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 German βš– 136 KB

An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)-2-azido-3methylbutanoic acid followed by reduction (Scheme 2).