A Concise Route to Valacyclovir Hydrochl
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Prasada Raju V. N. K. V. Vetukuri; Ravindra Vedantham; Vijayavitthal Thippannach
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Article
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2011
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John Wiley and Sons
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German
β 136 KB
An efficient and concise synthesis of valacyclovir hydrochloride (4), which is a prodrug of acyclovir (3) is described. The synthesis was accomplished in two stages by coupling acyclovir with (2S)-2-azido-3methylbutanoic acid followed by reduction (Scheme 2).