New pyridazinone derivatives as inhibitors of platelet aggregation
β Scribed by S Corsano; R Vezza; R Scapicchi; S Foresi; G Strappaghetti; GG Nenci; P Gresele
- Book ID
- 103630092
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 494 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0223-5234
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π SIMILAR VOLUMES
In a search for the inhibitors of platelet aggregation, certain coumarin derivatives were synthesized and evaluated for antiplatelet activity against thrornbin(Thr)-, arachidonic acid(AA)-, collagen(Co1)-, and platelet-activating-factor(PAF)-induced aggregation in washed rabbit platelets. These comp
a b s t r a c t New 6-substituted and 2,6-disubstituted pyridazinone derivatives were obtained starting from easily accessible alkyl furans by using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of this synthetic strategy. The new pyridazinone derivatives