New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities

✍ Scribed by Tamara Costas; Pedro Besada; Alessandro Piras; Laura Acevedo; Matilde Yañez; Francisco Orallo; Reyes Laguna; Carmen Terán

• Book ID: 104004885
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 267 KB
• Volume: 20
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.09.031

✦ Synopsis

a b s t r a c t New 6-substituted and 2,6-disubstituted pyridazinone derivatives were obtained starting from easily accessible alkyl furans by using oxidation with singlet oxygen to give 4-methoxy or 4-hydroxybutenolides, key intermediates of this synthetic strategy. The new pyridazinone derivatives have been studied as vasorelaxant and antiplatelet agents. Analysis of biological data revealed the silyl ethers (4a-i) and N,O-dibenzyl derivatives (6g-i) as the most active compounds.