New procedure for synthesis alkyl esters of 5-acetyl-2-furan-carboxylic acid alkyl ester
β Scribed by R. I. Khusnutdinov; A. R. Baiguzina; R. R. Mukminov; U. M. Dzhemilev
- Book ID
- 111462707
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2009
- Tongue
- English
- Weight
- 252 KB
- Volume
- 82
- Category
- Article
- ISSN
- 1070-4272
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π SIMILAR VOLUMES
The highly stereoselective ring opening of N-tosylaziridine 2-carboxylate esters with LiAIH4 followed by oxidation of the ensuing syn alcohols results in a highly efficient 4 step asymmetric synthesis of a-methyl I~-amino acids from N-sulfinylaziridine 2-carboxylate esters.
Deprotonation of alanine ester imines with KO'Bu in DMSO or DMF and alkylation of the formed enolates with several 2-fluoroalkyl halogenides 2 and subsequent hydrolysis of the imino and the ester groups are presented as an efficient three-step sequence for the synthesis of racemic title compounds 5.
Aziridine 2-Carboxylate Ester Mediated Asymmetric Synthesis of Ξ±-Alkyl Ξ²-Amino Acids. -Highly stereoselective reductive ring opening of the N-tosylaziridines (II) with LiAlH4 followed by oxidation of the syn-amino alcohols (III) provides an efficient entry to the asymmetric synthesis of Ξ±methyl Ξ²-am