AbstractΓA crude extract of a marine sponge showed initial inhibitory bioactivities in a yeast assay for inhibitors of methionine aminopeptidase-2 (Met AP-2). Bioassay-directed fractionation indicated that the activity was concentrated in the CH 2 Cl 2 -soluble fraction, and chromatography on silica
New manzamine alkaloids from a sponge of the genus xestospongia
β Scribed by Toshio Ichiba; Ryuichi Sakai; Shigeo Kohmoto; Gabriel Saucy; Tatsuo Higa
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 278 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
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## Abstract For Abstract see ChemInform Abstract in Full Text.
Four novel alkaloids of the aaptamine class have been isolated in addition to the known aaptamine, isoaaptamine, demethyl(oxy)aaptamine and its dimethylketal from an unidentified species of Indonesian marine sponge of the genus Xestospongia. Their structures were elucidated on the basis of detailed
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