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Novel alkaloids of the aaptamine class from an Indonesian marine sponge of the genus Xestospongia

✍ Scribed by Laurent Calcul; Arlette Longeon; Ali Al Mourabit; Michèle Guyot; Marie-Lise Bourguet-Kondracki

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
156 KB
Volume
59
Category
Article
ISSN
0040-4020

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✦ Synopsis

Four novel alkaloids of the aaptamine class have been isolated in addition to the known aaptamine, isoaaptamine, demethyl(oxy)aaptamine and its dimethylketal from an unidentified species of Indonesian marine sponge of the genus Xestospongia. Their structures were elucidated on the basis of detailed 1D and 2D NMR spectroscopic data. Their antimicrobial activity was tested towards Gram (þ) (S. aureus), Gram (2) (E. coli, V. anguillarum) bacterial strains, a fungus (C. tropicalis); their cytotoxic activity was evaluated against KB cells.

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Aaptanone, a novel zwitterionic metaboli
Aaptanone, a novel zwitterionic metabolite of the aaptamine class with an oxygenated 1,6-naphthyridine core from the Vietnamese marine sponge Aaptos aaptos
✍ Natalia K. Utkina; Vladimir A. Denisenko; Mikhail A. Pushilin 📂 Article 📅 2009 🏛 Elsevier Science 🌐 French ⚖ 227 KB

A new zwitterionic compound, aaptanone, having a rare oxygenated 1,6-naphthyridine core, has been isolated from the Vietnamese marine sponge Aaptos aaptos, along with the known metabolites, aaptamine, isoaaptamine, and their hydrochloride salts. The structure of aaptanone was determined as 8-methoxy