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New Ligands for Regio- and Enantiocontrol in Pd-Catalyzed Allylic Alkylations

✍ Scribed by Roger Prétôt; Andreas Pfaltz

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
89 KB
Volume
37
Category
Article
ISSN
0044-8249

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✦ Synopsis

The branched, chiral products 1 are formed preferentially in the allylic alkylations in Equation (1) when the Pd catalyst contains the P,N ligand L* or derivatives thereof. The ligands are readily synthesized from commercially available precursors.

📜 SIMILAR VOLUMES

ChemInform Abstract: New Ligands for Reg
ChemInform Abstract: New Ligands for Regio- and Enantiocontrol in Pd-Catalyzed Allylic Alkylations.
✍ R. PRETOT; A. PFALTZ 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

Among several new ligands the (S,S)-BOP ligand affords the best results of regio-and stereoselectivity in the allylic alkylations of 1-and 3-aryl-2-propenyl acetates such as (I) and (V). Alkyl substituted analogues like (VI) react with distinctly lower selectivities in the presence of this ligand. -

Application of SDP Ligands for Pd-Cataly
Application of SDP Ligands for Pd-Catalyzed Allylic Alkylation
✍ Jian-Hua Xie; Hai-Feng Duan; Bao-Min Fan; Xu Cheng; Li-Xin Wang; Qi-Lin Zhou 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 145 KB 👁 1 views

## Abstract Chiral spiro diphosphines (SDP) are efficient ligands for the Pd‐catalyzed asymmetric allylic alkylation of 1,3‐diphenyl‐2‐propenyl acetate with dimethyl malonate and related nucleophiles. The newly synthesized ligand DMM‐SDP (**1e**) with 3,5‐dimethyl‐4‐methoxy groups on the __P__‐phen