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New Jaspamide Derivatives from the Marine Sponge Jaspis splendans Collected in Vanuatu 1

✍ Scribed by Zampella, Angela; Giannini, Clelia; Debitus, Cécile; Roussakis, Christos; D'Auria, Maria Valeria

Book ID
127390145
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
40 KB
Volume
62
Category
Article
ISSN
0163-3864

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Jaspines A and B: two new cytotoxic sphi
Jaspines A and B: two new cytotoxic sphingosine derivatives from the marine sponge Jaspis sp.
✍ Véronique Ledroit; Cécile Debitus; Catherine Lavaud; Georges Massiot 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 125 KB

The ethanolic extract of the sponge Jaspis sp. collected in Vanuatu showed cytotoxicity against KB tumour cells (IC 95 =10 mg/ml). A bioassay-guided fractionation led to the isolation of two new cytotoxic sphingosine derivatives, jaspine A and jaspine B. Structures were elucidated by spectroscopic m