New Jaspamide Derivatives with Antimicrofilament Activity from the Sponge Jaspis splendans.
β Scribed by Fulvio Gala; Maria Valeria D'Auria; Simona De Marino; Franco Zollo; Charles D. Smith; Jean E. Copper; Angela Zampella
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 20 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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The ethanolic extract of the sponge Jaspis sp. collected in Vanuatu showed cytotoxicity against KB tumour cells (IC 95 =10 mg/ml). A bioassay-guided fractionation led to the isolation of two new cytotoxic sphingosine derivatives, jaspine A and jaspine B. Structures were elucidated by spectroscopic m
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