New intermediates for the synthesis of oligonucleotides by the phosphite triester approach
โ Scribed by J.L. Fourrey; D.J. Shire
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 210 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Most of the published work on the chemical synthesis of oligonucleotides\* has involved the us8 of intermediates with unprotected lnternucleotide phosphodiester linkages. Such intermediates can usually be isolated only on a comparatively small scale and are sometimes difficult to obtain pure. Furthe
4,6-Dinitro-l-(mesitylene-2-sulphonyloxy)-benzotriazole [DMBT, (@)I, l-(mesitylene-2-sulphonyloxy)-4-nitro-6-trifluoromethylbenzotriazole (@) and 1-(mesitylene-2-sulphonyl)-4nitro-1,2,3-triazole [iso-MSNT, (211 are more reactive condensing agents in the phosphotriester approach to oligonucleotide sy