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New in vitro dissolution test apparatus

✍ Scribed by S. S. Nasir; L. O. Wilken Jr.; S. M. Nasir

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 471 KB
Volume: 68
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600680215

No coin nor oath required. For personal study only.

✦ Synopsis

A new in vitro dissolution test apparatus was designed and evaluated. Compressed tablets of drugs representing different solubility characteristics were tested at various air pressures and compared to dissolution patterns of similar tablets by the Levy beaker and USP methods. Air pressure of 46 mm generally was suitable for determining the dissolution rates of tablets. This new dissolution tester possibly can be useful in determining drug release from solid dosage forms and correlating it with in vivo bioavailability because dissolution rate can be controlled easily with the adjustment of air pressure without complicated changes in the apparatus, there is no excessive settling of particles, and complete drug dissolution can be achieved with no clogging of the screen.

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