𝔖 Bobbio Scriptorium
✦   LIBER   ✦

New efficient syntheses of α-diflyoromethyl- and α-trifluoromethyl-ornithine

✍ Scribed by Sergey N. Osipov; Alexander S. Golubev; Norbert Sewald; Klaus Burger

Book ID
104257696
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
134 KB
Volume
38
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

A new efficient method for the preparation of ornithine derivatives 3-5 is described. The key step of the synthesis is the regioselective alkylation ofimine 2 with propargyl amine !.

📜 SIMILAR VOLUMES

ChemInform Abstract: New Efficient Synth
ChemInform Abstract: New Efficient Syntheses of α-Difluoromethyl- and α- Trifluoromethyl-ornithine.
✍ S. N. OSIPOV; A. S. GOLUBEV; N. SEWALD; K. BURGER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

New Efficient Syntheses of α-Difluoromethyl-and α-Trifluoromethylornithine. -Ornithines (V), possessing a broad spectrum of biological activities including anticancer activity, are prepared in three steps. The key step is the regioselective alkylation of the imine (I) with the acetylide (II) in exc