Efficient Synthesis of Bicyclic α-Hydroxy-α-trifluoromethyl-γ-lactams.
✍ Scribed by Norio Shibata; Hiroyuki Fujimoto; Satoshi Mizuta; Shinichi Ogawa; Yumi Ishiuchi; Shuichi Nakamura; Takeshi Toru
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 31 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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Efficient Synthesis of γ-Oxo-and γ-Hydroxy-α-amino Acids. -Reduction of aminoester (Va) with Zn(BH 4 ) 2 permits intermediate isolation of the γ-hydroxy derivative, which is converted to lactone (IX) during silica gel chromatography. -(MERLA, B.;
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