New Efficient Method for the Total Synthesis of ( S , S )-Isodityrosine from Natural Amino Acids
β Scribed by Jung, Michael E.; Lazarova, Tsvetelina I.
- Book ID
- 120444439
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 39 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
An efficient, general, and racemization free method of covalently attaching No-F'KKXZ protected amino acids to solid supports for peptide synthesis is described. The process involves the preparation of 2,4-dichlorophenyl-Na-Fmoc-aminoaql-4-oxyn~sthylphenoxy acetates which can be used to directly and
## N-methyl amino acids, including L-abrine, and N-alkyl amino esters, were synthesized by reductive amination of O'Donnell's Schiff base amino esters with NaBH3CN and formaldehyde, or the appropriate aldehyde in CH3CN or THF in good to excellent yields, and with high purity.