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A Convenient Method for the Asymmetric Synthesis of Fluorinated α-Amino Acids from Alcohols

✍ Scribed by Drouet, Fleur; Noisier, Anaïs F. M.; Harris, Craig S.; Furkert, Daniel P.; Brimble, Margaret A.


Book ID
121690806
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
408 KB
Volume
2014
Category
Article
ISSN
1434-193X

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Convenient, large-scale asymmetric synth
✍ Vadim A Soloshonok; Hironari Ohkura; Alexander Sorochinsky; Natalia Voloshin; An 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 77 KB

The enantiopure p-toluenesulfinimines were found to be efficient as chiral imine equivalents in the high temperature Reformatsky-type additions with BrZnCF 2 COOEt affording an efficient approach to the enantiomerically pure a,a-difluoro-bamino acids. High chemical and stereochemical yields (drs>9:1