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Asymmetric Synthesis of α-Amino Acids under Operationally Convenient Conditions

✍ Scribed by Jörres, Manuel; Chen, Xia; Aceña, José Luis; Merkens, Carina; Bolm, Carsten; Liu, Hong; Soloshonok, Vadim A.


Book ID
124154265
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
417 KB
Volume
356
Category
Article
ISSN
1615-4150

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Convenient, large-scale asymmetric synth
✍ Vadim A Soloshonok; Hironari Ohkura; Alexander Sorochinsky; Natalia Voloshin; An 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 77 KB

The enantiopure p-toluenesulfinimines were found to be efficient as chiral imine equivalents in the high temperature Reformatsky-type additions with BrZnCF 2 COOEt affording an efficient approach to the enantiomerically pure a,a-difluoro-bamino acids. High chemical and stereochemical yields (drs>9:1