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New developments of the μ-selective opioid 3,8-diazabicyclo[3.2.1]octanes

✍ Scribed by G. Cignarella; S. Villa; D. Barlocco; W. Fratta; P. Fadda


Book ID
119179761
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
151 KB
Volume
31
Category
Article
ISSN
1043-6618

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A series of trimethyipiperazine derivatives, structurally related to the Ix-agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane, have been synthesized and teswxl in binding studies, using 3H-DAMGO as Ix-selective ligand. Their different affinity towards Ix-opioid receptors has been interpre